Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.

  title={Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.},
  author={Robert S. Mansbach and E N Brooks and Yong Li Chen},
  journal={European journal of pharmacology},
  volume={323 1},
The effects of CP-154,526 (butyl-ethyl-[2,5-dimethyl-7-(2,4,6 -trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine), a selective corticotropin releasing factor (CRF1) receptor antagonist, were examined in the learned helplessness procedure, a putative model of depression with documented sensitivity to diverse classes of antidepressant drugs. Rats were exposed to a series of inescapable foot shocks on three consecutive days and tested in a shock-escape procedure on the fourth day. Animals… CONTINUE READING
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