Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system

@article{Machado2012AntidepressantlikeEO,
  title={Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system},
  author={Daniele Machado and Vivian Binder Neis and Grasiela de Oliveira Balen and Andr{\'e} R. da Silva Colla and Mauricio P Cunha and Juliana Bastos Dalmarco and Moacir Geraldo Pizzolatti and Rui D.S. Prediger and A.L.S. Rodrigues},
  journal={Pharmacology Biochemistry and Behavior},
  year={2012},
  volume={103},
  pages={204-211}
}
Ursolic acid, a constituent from Rosmarinus officinalis, is a triterpenoid compound which has been extensively known for its anticancer and antioxidant properties. In the present study, we investigated the antidepressant-like effect of ursolic acid isolated from this plant in two predictive tests of antidepressant property, the tail suspension test (TST) and the forced swimming test (FST) in mice. Furthermore, the involvement of dopaminergic system in its antidepressant-like effect was… CONTINUE READING