Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression.

@article{Mode2017AntidepressantlikeEO,
  title={Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression.},
  author={Edyta Możdżeń and Agnieszka Wąsik and Irena Romańska and Jerzy Michaluk and Lucyna Antkiewicz-Michaluk},
  journal={Pharmacological reports : PR},
  year={2017},
  volume={69 3},
  pages={566-574}
}
BACKGROUND Most of the currently used antidepressant drugs are monoamine-based compounds, acting by the inhibition of re-uptake or metabolism of noradrenaline (NA) and/or serotonin (5-HT), because these neurotransmitters play a key role in the pathophysiology of depression. The aim of this study was to investigate the potential antidepressant-like activity… CONTINUE READING