Antidepressant-like effect of Kyllinga brevifolia rhizomes in male mice and chemical characterization of the components of the active ethyl acetate fraction.

@article{HellinIbarrola2016AntidepressantlikeEO,
  title={Antidepressant-like effect of Kyllinga brevifolia rhizomes in male mice and chemical characterization of the components of the active ethyl acetate fraction.},
  author={Mar{\'i}a C. Helli{\'o}n-Ibarrola and Yenny Montalbetti and O. Heinichen and Mar{\'i}a L. Kennedy and M A Campuzano and N L Alvarenga and Derlis A. Ibarrola},
  journal={Journal of ethnopharmacology},
  year={2016},
  volume={194},
  pages={
          1005-1011
        }
}
ETHNO-PHARMACOLOGICAL RELEVANCE Kyllinga brevifolia rhizomes (Cyperaceae) are used in Paraguayan traditional medicine as a refreshing beverage, and is claimed to own digestive, diuretic, sedative, tonic, antispasmodic and sudorific properties. [...] Key Method Treatments in all modalities were made 1h before swimming test. The KbF-ethyl-ac was analyzed by LC-DAD-ESI-MS and LC-ESI-MS/MS in order to identify the active components. Expand
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Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice
TLDR
Findings indicate that K. brevifolia exerts a weak sedative and an interesting anxiolytic-like effect in mice and suggest its potential usefulness for the treatment of anxiety in humans.
Antidepressant-like effect of the ethanolic extract from Suanzaorenhehuan Formula in mice models of depression.
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It is demonstrated that ethanolic SHF extract produced an antidepressant-like effect and the mechanism of action involves the serotonergic, noradrenergic and monoamine oxidase enzyme systems although underlying mechanism still remains to be further elucidated.
Anxiolytic and antidepressant-like effects of the hydroalcoholic extract from Aloysia polystachya in rats
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The results suggest that some of the components of the hydroalcoholic extract of A. polystachya, such as thujone and carvone among others, may have sedative, anxiolytic and antidepressant-like properties which deserve further investigation.
Evaluation of Anti-Aggressive Activity of Kyllinga brevifolia in Rodent Model of Aggression
TLDR
Findings suggest that Kyllinga brevifolia exhibits a general anti-offensive aggressive activity and may be relevant in the treatment of reactive aggression in humans.
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TLDR
An anxiolytic-like profile of action for the extract of Aloysia polystachya without sedative side effect is indicated, being this activity probably mediated by other mechanism than BDZ-bs modulation at the GABA(A) receptors.
Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes.
TLDR
The study identified a plant with potential hepatoprotective constituents which will be isolated and characterized in future.
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TLDR
Observations suggest that the rhizome of C. articulatus has pharmacological properties similar to those of sedatives, which probably explain at least part of the therapeutic efficiency claimed for this plant in traditional medicine.
Acute toxicity and general pharmacological effect on central nervous system of the crude rhizome extract of Kyllinga brevifolia Rottb.
TLDR
The crude hydro-alcoholic rhizome extract of Kyllinga brevifolia Rottb, a popular medicine used in Paraguay, was investigated on mice and produced a significant increase in the hypnotic effect induced by pentobarbital in a dose-dependent manner.
Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test.
TLDR
Results suggested that antidepressant properties of the ethanolic extract of Curcuma longa was mediated through regulations of neurochemical and neuroendocrine systems and it may be a useful agent against depression.
The antidepressant-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice.
TLDR
Results indicate an antidepressant-like profile of action for the hydro-ethanolic extract and the component(s) of the ethyl acetate fraction obtained from A. polystachya, which deserve further investigation.
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