Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress.

@article{Tang2015AntidepressantlikeAA,
  title={Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress.},
  author={Zhuo-Jun Tang and Wei Zou and Juan Yuan and Ping Zhang and Ying Y Tian and Zhi-Fang Xiao and Mang-Hong Li and Hai-jun Wei and Xiao-Qing Tang},
  journal={Behavioural pharmacology},
  year={2015},
  volume={26 5},
  pages={427-35}
}
Depression is highly prevalent in individuals with diabetes, and depressive symptoms are less responsive to current antidepressant therapies. Oxidative stress plays a major role both in the pathogenesis of diabetes and in major depression and anxiety disorders. Hydrogen sulfide (H2S), the third gaseous mediator, is a novel signaling molecule in the brain… CONTINUE READING