Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats.

@article{MolinaHernndez2006AntidepressantlikeAA,
  title={Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats.},
  author={Miguel Molina-Hern{\'a}ndez and Norma Patricia T{\'e}llez-Alc{\'a}ntara and Jul{\'i}an P{\'e}rez-Garc{\'i}a and Jorge Iv{\'a}n Olivera-Lopez and M. Teresa Jaramillo},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2006},
  volume={30 6},
  pages={1129-35}
}
This study describes the effects of intra-lateral septal infusions of different doses of the mGluR5 antagonist MTEP in the DRL-72 s paradigm and the elevated plus-maze test in rats, two behavioral models known to be sensitive to antidepressant-like and anxiolytic-like drug effects, respectively. Intra-lateral septal infusions of MTEP induced a dose-dependent (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increase in reinforced lever presses and a cohesive rightward shift of the inter… CONTINUE READING

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