Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors

@article{Singh1993AntidepressantlikeAO,
  title={Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors},
  author={Ashish Singh and Irwin Lucki},
  journal={Neuropharmacology},
  year={1993},
  volume={32},
  pages={331-340}
}
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
TLDR
F 11440, shown here to be a potent, selective, high efficacy 5-HT1A receptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.
Antidepressant-like behavioral effects of serotonin receptor agonists
The role of serotonin receptor subtypes in treating depression: a review of animal studies
TLDR
The involvement of 5- HT receptors in the antidepressant-like effects of SSRIs is complex and involves the orchestration of stimulation and blockade at different 5-HT receptor subtypes.
Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice
Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors
TLDR
Indorenate produces antidepressant-like actions in the FST that are mediated by the stimulation of 5-HT1A receptors.
Differences in the effects of 5-HT1A receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice
TLDR
It is unlikely that the difference in 5-HT1A properties between LAL and SAL mice is an adaptive compensatory reaction to changes in5-HT metabolism, and it is suggested that the behavioral effects of 8-OH-DPAT and S-15535 may be mediated by predominant activation of postsynaptic 5-hydroxyindoleacetic acid receptors in LAL mice and by presynaptic5- HT1A receptors in SAL mice.
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TLDR
The unique combination of 5‐HT1A agonist activity with 5-HT2 antagonist activity appears to confer potent anxiolytic‐like actions on WY‐50,324 that prompt additional exploration of the interactions between these receptor subtypes and their role in anxiety and other disorders.
Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior.
TLDR
Results suggest that central 5-HT1A receptors are involved in mediating the antidepressant-like effects of some drugs on DRL 72-s behavior and implies that these two receptors may be important in mediation of clinical drug effects in depression.
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Compared the actions of ketanserin and pipamperone and metergoline and methysergide on two behavioral responses in rats that are produced by the activation of 5-HT receptors, the order of relative potency for these drugs to block the head shake response was the same as their reported affinity for the 5- HT2 receptor, which suggests that the5-HT2 receptor is involved in the headshake response.
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TLDR
Evidence is reviewed that the antidepressant activity may be due to the activation of postsynaptic 5-HT1A receptors, although 5- HT1A receptor agonists also activate somatodendritic autoreceptors which diminish the release of 4-HT, and evidence does not support the involvement of a common metabolite 1-PP in the antidepressants activity of 5-ht1Aceptor-selective azapirones.
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