Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial.

@article{Furey2006AntidepressantEO,
  title={Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial.},
  author={Maura L. Furey and Wayne C. Drevets},
  journal={Archives of general psychiatry},
  year={2006},
  volume={63 10},
  pages={1121-9}
}
CONTEXT The need for improved therapeutic agents that more quickly and effectively treat depression is critical. In a pilot study we evaluated the role of the cholinergic system in cognitive symptoms of depression and unexpectedly observed rapid reductions in depression severity following the administration of the antimuscarinic drug scopolamine hydrobromide (4 microg/kg intravenously) compared with placebo (P = .002). Subsequently a clinical trial was designed to assess more specifically the… CONTINUE READING

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