Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.

@article{Murrough2013AntidepressantEO,
  title={Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.},
  author={James W. Murrough and Dan V. Iosifescu and Lee Chun Chang and Rayan K Al Jurdi and Charles A. Green and Andrew Perez and Syed Muhammad Zeeshan Iqbal and Sarah Pillemer and Alexandra L Foulkes and Asim H. Shah and Dennis S. Charney and Sanjay J. Mathew},
  journal={The American journal of psychiatry},
  year={2013},
  volume={170 10},
  pages={1134-42}
}
OBJECTIVE Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. METHOD This was a two-site, parallel-arm, randomized controlled trial of a single infusion of ketamine compared to an… CONTINUE READING
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Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
Ketamine , a glutamate N - methyl - d - aspartate ( NMDA ) receptor antagonist , has shown rapid antidepressant effects , but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion .
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