Antidepressant effects of ketamine in depressed patients.

  title={Antidepressant effects of ketamine in depressed patients.},
  author={Robert M. Berman and Angela Cappiello and Amit Anand and Dan A. Oren and George R. Heninger and Dennis S. Charney and John H. Krystal},
  journal={Biological psychiatry},
  volume={47 4},
BACKGROUND A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression. METHODS Seven subjects with major depression completed 2 test days that involved intravenous treatment with… CONTINUE READING
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