Antidepressant effects of ketamine in depressed patients

@article{Berman2000AntidepressantEO,
  title={Antidepressant effects of ketamine in depressed patients},
  author={Robert M. Berman and Angela Cappiello and Amit Anand and Dan A. Oren and George R. Heninger and Dennis S. Charney and John H. Krystal},
  journal={Biological Psychiatry},
  year={2000},
  volume={47},
  pages={351-354}
}
BACKGROUND A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression. METHODS Seven subjects with major depression completed 2 test days that involved intravenous treatment with… Expand

Paper Mentions

Interventional Clinical Trial
Ketamine is a medication that came into clinical practice in the 1960's. Ketamine is used as an anesthetic and to provide pain relief. Recently, Ketamine was approved to treat drug… Expand
ConditionsDrug Resistant Epilepsy, Medically Refractory Epilepsy, Refractory Epilepsy
InterventionDrug
Interventional Clinical Trial
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar… Expand
ConditionsKetamine, Postpartum Depression, Prenatal Depression
InterventionDrug
Interventional Clinical Trial
Postpartum depression is common in mothers early after childbirth and produces harmful effects not only on mothers, but also on infants and young children. Parturients with… Expand
ConditionsKetamine, Perinatal Depression, Postpartum Depression
InterventionDrug
Interventional Clinical Trial
The treatment of resistant depression should be optimized aiming at complete remission of symptoms, a complex condition due to several factors. Approximately 1/3 of patients with… Expand
ConditionsDepressive Disorder
InterventionDevice, Diagnostic Test, Drug, (+1 more)
Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
TLDR
The present results suggested that direct AMPA receptor activation may play an important role in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression, although other mechanisms might be involved in the sustained action. Expand
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
TLDR
Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week. Expand
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.
TLDR
A substantial relationship between ketamine's antidepressant and psychotomimetic effects was found, and this relationship could be mediated by the initial steps of ketamine’s action, trough NMDA receptors, shared by both ketamines' clinical effects. Expand
Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder
TLDR
It was shown that ketamine is as effective as ECT in improving depressive symptoms in MDD patients and have more rapid antidepressant effects compared with the ECT. Expand
The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects
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It is hypothesized that ketamine directly mediates this throughput, whereas monoaminergic antidepressants work indirectly and gradually; this may explain, in part, the lag of onset of several weeks to months that is observed with traditional antidepressants. Expand
A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
TLDR
This study provides the first controlled evidence for the rapid antidepressant effects of intranasal ketamine and may lead to novel approaches to the pharmacologic treatment of patients with major depression. Expand
Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
TLDR
This study replicated the previous finding that patients with bipolar depression who received a single ketamine infusion experienced a rapid and robust antidepressant response, and found that ketamine rapidly improved suicidal ideation in these patients. Expand
Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting
TLDR
Ketamine, at a dose of 0.5 mg/kg, given just before ECT, did not enhance the antidepressant effect of ECT and the results suggest that the coadministration of ketamine with a barbiturate anesthetic and ECT may attenuate the immediate antidepressant effects of the N-methyl-D-aspartate antagonist. Expand
Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression
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This is the first report to the authors' knowledge to demonstrate the dose-related efficacy of R/S-ketamine for treatment-resistant depression and the first to characterize ketamine effects in a genotyped Chinese population in which most patients possessed at least one copy of the lower functioning Met allele of the BDNF gene. Expand
Ketamine: A Promising Rapid-Acting Antidepressant
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Emerging evidence suggests a strong role for the glutamatergic system in the pathophysiology of mood disorders, which may provide more efficient therapeutic targets in the development of novel antidepressants. Expand
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