Antidepressant effects of ketamine in depressed patients

@article{Berman2000AntidepressantEO,
  title={Antidepressant effects of ketamine in depressed patients},
  author={Robert M. Berman and Angela Cappiello and Amit Anand and Dan A. Oren and George R. Heninger and Dennis S. Charney and John H. Krystal},
  journal={Biological Psychiatry},
  year={2000},
  volume={47},
  pages={351-354}
}

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References

SHOWING 1-10 OF 32 REFERENCES
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.
TLDR
It is proposed that adaptive changes in NMDA receptors may be the final common pathway for antidepressant action.
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
TLDR
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Loading dose imipramine--new approach to pharmacotherapy of melancholic depression.
Pulse intravenous clomipramine for depressed adolescents: double-blind, controlled trial.
TLDR
Pulse clomipramine (200 mg i.v.) is associated with dramatic reduction in depressive symptoms at day 6 after infusion, which is significantly different from the effect of placebo.
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression.
Acute antidepressant effect following pulse loading with intravenous and oral clomipramine.
TLDR
Pronounced early improvements in severe depressive symptoms may be achieved via loading dose regimens with clomipramine in the absence of continuous treatment, as was the amelioration in the Raskin Severity for Depression Scale and the Beck Depression Inventory scores.
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.
Reduction of NMDA-induced behaviour after acute and chronic administration of desipramine in mice
...
...