Corpus ID: 203657160

Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression.

@article{Yan2019AntidepressantEO,
  title={Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression.},
  author={Yongmei Yan and Tao Li and Dou Wang and Bingbing Zhao and Qi Zhou},
  journal={Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan},
  year={2019},
  volume={39 5},
  pages={
          658-666
        }
}
  • Yongmei Yan, Tao Li, +2 authors Qi Zhou
  • Published 2019
  • Medicine
  • Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
OBJECTIVE To identify the antidepressant effect of Xingnao Jieyu (XNJY) decoction on a post-stroke depression (PSD) rat model and the underlying molecular mechanism. METHODS We established a rat PSD model by middle cerebral artery occlusion (MCAO) combined with chronic unpredictable mild stress (CUMS). Healthy SD rats were randomly divided into six groups: sham, PSD, fluoxetine (Flu), and XNJY groups at low, middle, and high doses. The sham group underwent sham operation, while the other… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Xingnao Jieyu Decoction Ameliorates Poststroke Depression through the BDNF/ERK/CREB Pathway in Rats
TLDR
Results indicated that the XNJY decoction exerts an obvious antidepressant effect, which may be due to the regulation of the BDNF/ERK/CREB signaling pathway. Expand
The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine
TLDR
Results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hippocampi of rats with post-stroke depression, and exert antidepressant effects. Expand
Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats.
TLDR
The decrease in BDNF expression in the hippocampus of PSD rats may aggravate cognitive impairment, however, the degree of cognitive impairment cannot be reflected by the expression levels of -derived brain-derived neurotrophic factor (BDNF) in the hippocampi. Expand
The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression.
  • M. Maes
  • Medicine, Biology
  • Neuro endocrinology letters
  • 2008
This paper hypothesizes that inflammatory, oxidative and nitrosative (IO&NS) pathways, and an increased translocation of LPS from gram-negative bacteria are causally related to depression followingExpand
Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
TLDR
The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine, and the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac. Expand
Neuronal Apoptosis and Synaptic Density in the Dentate Gyrus of Ischemic Rats’ Response to Chronic Mild Stress and the Effects of Notch Signaling
TLDR
It is found that post-stroke stressors made neurons in the dentate gyrus vulnerable to apoptosis, which supports a putative role for Notch signaling in neural integrity, potentially in newborn cells’ synaptic deficit with regard to preexisting cells. Expand
The role of orexin in post-stroke inflammation, cognitive decline, and depression
TLDR
This review advances the understanding of the role of orexin in post-stroke pathologies, focusing on its possible function as a therapeutic regulator in the post-ischemic brain. Expand
(Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors
TLDR
The initial so-called “monocyte-T lymphocyte”, “cytokine” or “inflammatory” hypothesis was based on findings on increased levels of proinflammatory cytokines produced by monocytic cells/macrophages in depression. Expand
The Effects of Chronic Fluoxetine Treatment on Chronic Mild Stress-Induced Cardiovascular Changes and Anhedonia
TLDR
Evidence is provided that 4 weeks of fluoxetine treatment can prevent behavioral responses and can partially prevent cardiovascular changes associated with CMS, providing insight into the role of serotonin in the link between depression and cardiovascular dysfunction. Expand
Inflammatory mechanisms in ischemic stroke: therapeutic approaches
TLDR
The molecular aspects of oxidative stress and inflammation in ischemic stroke and potential therapeutic strategies that target neuroinflammation and the innate immune system are discussed. Expand
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