Corpus ID: 203657160

Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression.

  title={Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression.},
  author={Yongmei Yan and Tao Li and Dou Wang and Bingbing Zhao and Qi Zhou},
  journal={Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan},
  volume={39 5},
  • Yongmei Yan, Tao Li, +2 authors Qi Zhou
  • Published 2019
  • Medicine
  • Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
OBJECTIVE To identify the antidepressant effect of Xingnao Jieyu (XNJY) decoction on a post-stroke depression (PSD) rat model and the underlying molecular mechanism. METHODS We established a rat PSD model by middle cerebral artery occlusion (MCAO) combined with chronic unpredictable mild stress (CUMS). Healthy SD rats were randomly divided into six groups: sham, PSD, fluoxetine (Flu), and XNJY groups at low, middle, and high doses. The sham group underwent sham operation, while the other… Expand
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