Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription - a possible mechanism.

@article{Budziszewska2000AntidepressantDI,
  title={Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription - a possible mechanism.},
  author={Bogustawa Budziszewska and Lucylla Jaworska-Feil and Małgorzata Kajta and Władysław Lasoń},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 6},
  pages={1385-93}
}
1. Antidepressant drugs are known to inhibit some changes evoked by glucocorticoids, as well as a hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, often observed in depression. 2. The aim of present study was to investigate effects of various antidepressant drugs on the glucocorticoid-mediated gene transcription in fibroblast cells, stably transfected with an MMTV promoter (LMCAT cells). 3. The present study have shown that antidepressants (imipramine, amitriptyline, desipramine… CONTINUE READING

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