Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice

@article{Cott2005AntidepressantDA,
  title={Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice},
  author={J. Cott and S. Ögren},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={48},
  pages={223-240}
}
  • J. Cott, S. Ögren
  • Published 2005
  • Chemistry, Medicine, Psychology
  • Journal of Neural Transmission
The interactions between ethanol and antidepressant drugs (both tricyclics and newer non-tricyclics) were studied in mice. The ability of these drugs to enhance the sedative effects of ethanol at two different doses (3.2 and 4.0 g/kg) was measured. The percentage of mice losing the righting-reflex was used for the lower dose, and the duration of ethanol-induced sleep was used at the higher dose. The relative order of potency was amitriptyline>-imipramine>maprotiline=mianserin>desipramine… Expand
Mianserin, but not Ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats
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