Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice

  title={Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice},
  author={J. Cott and S. Ögren},
  journal={Journal of Neural Transmission},
  • J. Cott, S. Ögren
  • Published 2005
  • Chemistry, Medicine, Psychology
  • Journal of Neural Transmission
The interactions between ethanol and antidepressant drugs (both tricyclics and newer non-tricyclics) were studied in mice. The ability of these drugs to enhance the sedative effects of ethanol at two different doses (3.2 and 4.0 g/kg) was measured. The percentage of mice losing the righting-reflex was used for the lower dose, and the duration of ethanol-induced sleep was used at the higher dose. The relative order of potency was amitriptyline>-imipramine>maprotiline=mianserin>desipramine… Expand
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Findings further support a major role for NET and the alpha2-adrenoreceptor in modulating the depressant effects of ethanol, with possible implications for understanding the role of noradrenergic dysfunction in stress-related alcoholism. Expand
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Modulation of the acute stimulating effect of ethanol by two anxiolytic drugs, Mianserin and Ondansetron, are explored to highlight the importance of stress as a modulator of the effects of ethanol during early developmental stages. Expand
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Effects of amitriptyline and zimelidine in combination with ethanol
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Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study
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The effect of antidepressants and “tranquillizers” on the response of mice to ethanol
  • G. Milner
  • Medicine
  • British journal of pharmacology
  • 1968
Methylphenidate and desipramine protected the mice against ethanol induced coma and induced statistically significant potentiation of the depressant and toxic effects of ethanol in mice. Expand
Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs
The therapeutic action of antidepressant drugs may in part be due to a reduced functional activity of some central 5-HT systems, and a new indoleamine hypothesis of depression is presented. Expand
Activity of the compounds in antagonizing reserpine-induced ptosis in rabbits and prolongation of alcohol hypnosis in mice give good correlation with their clinical actions, whilst their activities in augmenting excitation of rats by amphetamine and yohimbine toxicity in mice offer further evidence for drug-induced sensitization to adrenergic or tryptaminic mechanisms. Expand
Interaction between centrally acting hypotensive drugs and tricyclic antidepressants.
The antagonism of clonidine and alpha-methyl-DOPA reflects a general interaction between centrally acting hypotensive drugs and tricylclic antidepressants, and seems likely that the antagonism occurs at the level of central alpha-adrenoreceptors in the brain stem. Expand
Interactions of tricyclic antidepressants and barbiturates in barbiturate-tolerant and nontolerant rats.
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A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices.
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Tricyclic antidepressant agents. II. Effect of oral administration on the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices of the midbrain-hypothalamus region of the rat.
The inhibition of the simultaneous uptake of 3-H-l-noradrenaline (NA) and 14-C-5-hydroxytryptamine (5-HT) in slices of the midbrain-hypothalamus region of the rat brain after oral administration ofExpand
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Effects of antidepressant drugs on different receptors in the brain.
Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors and found that all the antidepressants tested were practically devoid of activity on DHA binding, Spiroperidol binding, [3H]flunitrazepam binding, and Naloxone binding. Expand
Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain
The effect of electroconvulsive treatment, as it is generally accepted to be one of the most effective treatments for severe depression, is tested, on the reactivity of the cyclic AMP-generating system to NA. Expand