Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

@article{Singh2007AntidepressantBS,
  title={Antidepressant binding site in a bacterial homologue of neurotransmitter transporters},
  author={Satinder K. Singh and Atsuko Yamashita and Eric Gouaux},
  journal={Nature},
  year={2007},
  volume={448},
  pages={952-956}
}
Sodium-coupled transporters are ubiquitous pumps that harness pre-existing sodium gradients to catalyse the thermodynamically unfavourable uptake of essential nutrients, neurotransmitters and inorganic ions across the lipid bilayer. Dysfunction of these integral membrane proteins has been implicated in glucose/galactose malabsorption, congenital hypothyroidism, Bartter’s syndrome, epilepsy, depression, autism and obsessive-compulsive disorder. Sodium-coupled transporters are blocked by a number… 

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