Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test.

  title={Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test.},
  author={Leandro Ciulla and Hon{\'o}rio Sampaio Menezes and B{\'a}rbara Beatriz Moreira Bueno and Alexandre Schuh and Rafael Jos{\'e} Vargas Alves and Milena Pacheco Abegg},
  journal={Acta cirurgica brasileira},
  volume={22 5},
PURPOSE To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the… CONTINUE READING

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