Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients.

@article{ElMallakh2008AntidepressantassociatedCI,
  title={Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients.},
  author={Rif S El-Mallakh and S. Nassir Ghaemi and Kemal Sagduyu and Michael E Thase and Stephen R. Wisniewski and Andrew A. Nierenberg and Hong Wei Zhang and Tamara A Pardo and Gary Sachs},
  journal={Journal of affective disorders},
  year={2008},
  volume={111 2-3},
  pages={
          372-7
        }
}
BACKGROUND It has been proposed that antidepressants can induce a chronic, dysphoric, irritable state in bipolar patients (called ACID for antidepressant-associated chronic irritable dysphoria). This phenomenon has only been described in case series format, and has not been prospectively validated. METHODS Prospective data from the first 1500 patients (62.7% with bipolar I, 30.1% with bipolar II, and 7.2% with NOS) treated in the STEP-BD database were examined and those who were euthymic for… CONTINUE READING

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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder.

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