Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models

@inproceedings{Pytka2015AntidepressantAA,
  title={Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models},
  author={Karolina Pytka and Anna Partyka and Magdalena Jastrzębska-Więsek and Agata Siwek and Monika Głuch-Lutwin and Barbara Mordyl and Grzegorz Kazek and Anna Rapacz and Adrian Olczyk and Adam Gałuszka and Marian Błachuta and Anna M Waszkielewicz and Henryk Marona and Jacek Sapa and Barbara Filipek and Anna Wesołowska and Judith R Homberg},
  booktitle={PloS one},
  year={2015}
}
The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding and functional in vitro assays as well as in vivo models. Antidepressant-like properties were investigated in the forced swim test (FST) in mice and rats… CONTINUE READING
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