Antidepressant Prescription Pattern in the Presence of Medical Co-morbidity: REAP-AD 2013 Study.


OBJECTIVE To evaluate the prescription pattern of antidepressants in patients with medical co-morbidity from major psychiatric centres in Asia. METHODS The Research on Asian Psychotropic Prescription Pattern for Antidepressants (REAP-AD 2013) collected data from 42 psychiatric centres in 10 Asian countries and regions. Antidepressant prescriptions of 2320 patients with various psychiatric disorders were evaluated. Of these, 370 patients who had specified medical co-morbidities formed the study cohort. RESULTS Escitalopram (20%) and mirtazapine (20%) were the most commonly prescribed antidepressants in patients with medical co-morbidity followed by sertraline (16%), trazodone (15%), and paroxetine (12%). Overall, more than half (52%; 247/476) of prescriptions comprised selective serotonin reuptake inhibitors. Slightly less than two-thirds (63%; n = 233) of patients received at least 1 selective serotonin reuptake inhibitor. In addition, 79% of patients were prescribed only 1 antidepressant. The mean number of antidepressants used per patient was 1.25 (standard deviation, 0.56). There were subtle differences in the most preferred antidepressant across medical illnesses such as diabetes mellitus, liver dysfunction, acid peptic disease, and cerebrovascular disease. Differences were also seen in prescription patterns across different countries. CONCLUSION Although selective serotonin reuptake inhibitors formed the bulk of antidepressant prescriptions in the presence of medical co-morbidity, mirtazapine was also commonly used in the presence of medical co-morbidities. Specified medical morbidities do influence the selection of antidepressants.

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@article{Grover2015AntidepressantPP, title={Antidepressant Prescription Pattern in the Presence of Medical Co-morbidity: REAP-AD 2013 Study.}, author={Sandeep Grover and Ajit K. Avasthi and Adarsh Tripathi and Andi Jayalangkara Tanra and K Y Chee and Yulong He and Helen Fung-Kum Chiu and Hironori Kuga and Myung Sik Lee and M Y Chong and Pichet Udormatn and Shigenobu Kanba and Shi Yang and Tian-Mei Si and Kang Hee Sim and Cher Heng Tan and Winston Wu-Dien Shen and Yu-Tao Xiang and Norman Sartorius and Naotaka Shinfuku}, journal={East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan}, year={2015}, volume={25 3}, pages={99-107} }