Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review

@article{Molero2018AntidepressantEA,
  title={Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review},
  author={P. Molero and J. Ramos-Quiroga and R. Mart{\'i}n-Santos and E. Calvo-S{\'a}nchez and L. Guti{\'e}rrez-Rojas and J. Meana},
  journal={CNS Drugs},
  year={2018},
  volume={32},
  pages={411-420}
}
Ketamine and its enantiomer S-ketamine (esketamine) are promising candidates to produce a rapid-onset antidepressant effect in treatment-resistant depression. Ketamine causes continued blockade of the glutamate N-methyl-d-aspartate (NMDA) receptor, though this might not primarily mediate the antidepressant effect. Alternative hypotheses include selectivity for the NMDA receptor subtype containing the NMDA receptor subunit 2B (NR2B), inhibition of the phosphorylation of the eukaryotic elongation… Expand
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