Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study

  title={Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study},
  author={R. Sanches and F. de Lima Os{\'o}rio and R. D. Dos Santos and L. R. Macedo and J. P. Maia-de-Oliveira and Lauro Wichert-Ana and D. de Ara{\'u}jo and J. Riba and J. Crippa and J. Hallak},
  journal={Journal of Clinical Psychopharmacology},
  • R. Sanches, F. de Lima Osório, +7 authors J. Hallak
  • Published 2016
  • Medicine, Psychology
  • Journal of Clinical Psychopharmacology
  • Abstract Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on regional cerebral blood flow. In an open… CONTINUE READING
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