Antidepressant Effects and Mechanisms of the Total Iridoids of Valeriana jatamansi on the Brain-Gut Axis.

  title={Antidepressant Effects and Mechanisms of the Total Iridoids of Valeriana jatamansi on the Brain-Gut Axis.},
  author={Liwen Wang and Yong-Qiao Sun and Tingting Zhao and Yongbiao Li and Xiaoqin S. Zhao and Li Zhang and Lanlan Wu and Liudai Zhang and Tiane Zhang and Guihua Wei and Alvin M Altamirano and Yan Tong and Zhiyong Yan},
  journal={Planta medica},
Valeriana jatamansi is widely used in Chinese folk medicine and contains iridoids as important active ingredients. The brain-gut axis describes a complex bidirectional system between the central nervous system and the gastrointestinal tract. Herein, we evaluated the antidepressant effects of total iridoids of Valeriana jatamansi (TIV) and preliminarily investigated the effects of gut microbiota on their antidepressant effects using a chronic, unpredictable mild-stress mouse model. Mice were… Expand
Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway
  • Li Zhang, Liwen Wang, +16 authors Zhiyong Yan
  • Medicine
  • Pharmaceutical biology
  • 2021
TIV may modulate the intestinal flora, thereby inducing the expression of ZO-1 and occludin and activating the BBB and exerting an antidepressant effect in mice. Expand
Schisandra chinensis ameliorates depressive‐like behaviors by regulating microbiota‐gut‐brain axis via its anti‐inflammation activity
Results suggested that lignans is the effective fraction of S.chinensis to ameliorating depressive disorders, which its anti‐inflammation activity possibly involved in the bidirectional connection between gut microbiota and brain. Expand
Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
The antidepressant activity of Spathodea campanulata flowers was evaluated in mice and in silico and data suggest that S. campanULata flowers warrants further investigation as a source of novel templates for antidepressive drugs. Expand
Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System
The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. Expand
Comprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry
The results not only detailedly elucidated many new metabolites and metabolic pathways of swertiamarin, but also provided a reference for further study of its pharmacological mechanism and evaluation of its safety. Expand
Phytochemical analysis of high value medicinal plant Valeriana jatamansi using LC-MS and it's in-vitro anti-proliferative screening
Abstract Background Phytochemicals are group of compounds derived from plant resource and shown to have many pharmacological activities. Identification and quantification of chemical constituents inExpand


Involvement of nitric oxide (NO) signalling pathway in the antidepressant activity of essential oil of Valeriana wallichii Patchouli alcohol chemotype.
It is demonstrated that nitric oxide pathway is involved in mediating antidepressant like effect of essential oil from this chemotype in both acute and chronic treatment study using forced swim test. Expand
Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report.
The results suggest that V wallichii may be useful in the treatment of stress related disorders in human and may be a promising anti-stress agent in near future. Expand
Protective effect of Radix Acanthopanacis Senticosi capsule on colon of rat depression model.
Enhanced colon inflammatory response and oxidative stress were observed in the chronic stress-induced rat depression model, which manifested as the significant increase of MDA, iNOS and NO levels, as well as the expressions of COX-2 in the colon tissue, but the colonic SOD activity was significantly decreased compared with the normal control. Expand
Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress
It is demonstrated that NaB significantly improved depression-like behaviors in CUMS-induced mice and its antidepressant actions might be related with, at least in part, the increasing brain 5-HT concentration and BDNF expression and restoring BBB impairments. Expand
Terpenoid content of Valeriana wallichii extracts and antidepressant‐like response profiles
Qualitative phytochemical analysis revealed that the aqueous‐ethanolic extract of V. wallichii was the only separated rhizome fraction containing terpenoids, suggesting that the antidepressant‐like action of this herbal plant is not contingent upon its terpenoid constituents. Expand
Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment
The ACTH model may have utility for the identification of novel treatments for TRD because it does not show a depression‐like phenotype and upon cessation, the effects of ACTH are not sustained. Expand
Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model.
Direct evidence is provided to support the antidepressant effects of ginsenoside Rg3, potentially indicating its application in the treatment of clinical depression. Expand
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
  • E. Quigley
  • Biology, Medicine
  • Current Neurology and Neuroscience Reports
  • 2017
In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited and a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders. Expand
Effects of Monoamines and Antidepressants on Astrocyte Physiology: Implications for Monoamine Hypothesis of Depression
The gene expression and metabolic changes brought about by antidepressants in astrocytes are discussed, which could be of relevance to synaptic plasticity and behavioral effects of antidepressant treatments. Expand
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
Results show that the central CRF system is altered in both animal models, which may affect HPA axis regulation, contribute to behavioural changes associated with stress-related disorders, and alter the affective component of visceral pain modulation, which is enhanced in IBS patients. Expand