Antidepressant Effects and Mechanisms of the Total Iridoids of Valeriana jatamansi on the Brain-Gut Axis.

@article{Wang2019AntidepressantEA,
  title={Antidepressant Effects and Mechanisms of the Total Iridoids of Valeriana jatamansi on the Brain-Gut Axis.},
  author={Liwen Wang and Yong-Qiao Sun and Tingting Zhao and Yongbiao Li and Xiaoqin S. Zhao and Li Zhang and Lanlan Wu and Liudai Zhang and Tiane Zhang and Guihua Wei and Alvin M Altamirano and Yan Tong and Zhiyong Yan},
  journal={Planta medica},
  year={2019}
}
Valeriana jatamansi is widely used in Chinese folk medicine and contains iridoids as important active ingredients. The brain-gut axis describes a complex bidirectional system between the central nervous system and the gastrointestinal tract. Herein, we evaluated the antidepressant effects of total iridoids of Valeriana jatamansi (TIV) and preliminarily investigated the effects of gut microbiota on their antidepressant effects using a chronic, unpredictable mild-stress mouse model. Mice were… Expand
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