Antidepressant Discontinuation Syndromes

@article{Haddad2001AntidepressantDS,
  title={Antidepressant Discontinuation Syndromes},
  author={Peter M. Haddad},
  journal={Drug Safety},
  year={2001},
  volume={24},
  pages={183-197}
}
  • P. Haddad
  • Published 2001
  • Medicine, Psychology
  • Drug Safety
Discontinuation symptoms are recognised with tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs) and miscellaneous antidepressants. A wide variety of symptoms have been described, differing somewhat between antidepressant classes, and several symptom clusters or discontinuation syndromes appear to exist. A common feature is onset within a few days of stopping the antidepressant or, less commonly, reducing the dosage. Discontinuation syndromes… 
Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs.
TLDR
Alternative strategies that do not encompass continuation of antidepressant treatment are required, but there is currently lack of adequate research for guiding the clinical approach.
Pharmacotherapy of Mood Disorders and Treatment Discontinuation
TLDR
The antidepressant discontinuation syndrome is characterised by the time-locked emergence of new, clearly defined and quantifiable signs and symptoms that ensue on stopping or reducing the dose of an antidepressant, and meets the criteria for a withdrawal syndrome.
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
TLDR
The present overview aimed at analyzing the literature to illustrate withdrawal after decrease, discontinuation, or switch of psychotropic medications based on the drug class, finding that benzodiazepines should be substituted by medications that cause less dependence such as antidepressants and antipsychotics runs counter the available literature.
A Dispensing Error Resulting in Possible Fluoxetine Overdose and Subsequent Discontinuation Syndrome in a Child
TLDR
A case of SSRI discontinuation syndrome is reported in a pediatric patient who was erroneously dispensed fluoxetine (Prozac) and the clinical problems often associated with dispensing errors are demonstrated, especially as it relates to the pediatric population.
Antidepressant discontinuation syndrome.
  • D. Antai-Otong
  • Psychology, Medicine
    Perspectives in psychiatric care
  • 2003
TLDR
There is growing evidence that a sizeable number of patients who are nonadherent or who abruptly discontinue SSRIs and other novel and older antidepressants report somatic, mood, and psychomotor symptoms or discontinuation syndrome.
Discontinuation symptoms in users of selective serotonin reuptake inhibitors in clinical practice: tapering versus abrupt discontinuation
TLDR
One in five patients abruptly discontinued their SSRI therapy in clinical practice, and the effect of tapering with that of abrupt discontinuation on the occurrence of discontinuation symptoms was compared.
[Antidepressant discontinuation syndrome--a problem for the clinician and the patient].
TLDR
Patients' and their families' psychoeducation is still considered a key factor in the management of antidepressant discontinuation syndrome, and clinicians should educate patients about possibility and nature of discontinuation symptoms, the importance of taking medication consistenly.
Discontinuation Syndrome in Dysthymic Patients Treated with Selective Serotonin Reuptake Inhibitors
TLDR
A discontinuation syndrome is common after treatment with SSRIs is stopped in patients with dysthymia, and it appears to be more common in patients receiving paroxetine than in those receiving fluoxettine.
Neonatal symptoms following maternal paroxetine treatment: Serotonin toxicity or paroxetine discontinuation syndrome?
TLDR
It is recommended that all neonates exposed to antidepressants during the last trimester should be followed-up closely for adverse symptoms commencing in the first 10 days after birth, though an important differential diagnosis is a paroxetine discontinuation (withdrawal) syndrome.
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  • Medicine, Psychology
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A characteristic selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome appears to exist. It is usually mild, commences within 1 week of stopping treatment, resolves spontaneously
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OBJECTIVE To demonstrate that when antidepressants are switched, discontinuation symptoms from the first antidepressant may be misdiagnosed as adverse effects of the second antidepressant. METHOD
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