Antidepressant Discontinuation Syndromes

  title={Antidepressant Discontinuation Syndromes},
  author={Peter M. Haddad},
  journal={Drug Safety},
  • P. Haddad
  • Published 2001
  • Medicine, Psychology
  • Drug Safety
Discontinuation symptoms are recognised with tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs) and miscellaneous antidepressants. A wide variety of symptoms have been described, differing somewhat between antidepressant classes, and several symptom clusters or discontinuation syndromes appear to exist. A common feature is onset within a few days of stopping the antidepressant or, less commonly, reducing the dosage. Discontinuation syndromes… 
Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs.
Alternative strategies that do not encompass continuation of antidepressant treatment are required, but there is currently lack of adequate research for guiding the clinical approach.
Pharmacotherapy of Mood Disorders and Treatment Discontinuation
The antidepressant discontinuation syndrome is characterised by the time-locked emergence of new, clearly defined and quantifiable signs and symptoms that ensue on stopping or reducing the dose of an antidepressant, and meets the criteria for a withdrawal syndrome.
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
The present overview aimed at analyzing the literature to illustrate withdrawal after decrease, discontinuation, or switch of psychotropic medications based on the drug class, finding that benzodiazepines should be substituted by medications that cause less dependence such as antidepressants and antipsychotics runs counter the available literature.
A Dispensing Error Resulting in Possible Fluoxetine Overdose and Subsequent Discontinuation Syndrome in a Child
A case of SSRI discontinuation syndrome is reported in a pediatric patient who was erroneously dispensed fluoxetine (Prozac) and the clinical problems often associated with dispensing errors are demonstrated, especially as it relates to the pediatric population.
Antidepressant discontinuation syndrome.
  • D. Antai-Otong
  • Psychology, Medicine
    Perspectives in psychiatric care
  • 2003
There is growing evidence that a sizeable number of patients who are nonadherent or who abruptly discontinue SSRIs and other novel and older antidepressants report somatic, mood, and psychomotor symptoms or discontinuation syndrome.
Discontinuation symptoms in users of selective serotonin reuptake inhibitors in clinical practice: tapering versus abrupt discontinuation
One in five patients abruptly discontinued their SSRI therapy in clinical practice, and the effect of tapering with that of abrupt discontinuation on the occurrence of discontinuation symptoms was compared.
[Antidepressant discontinuation syndrome--a problem for the clinician and the patient].
Patients' and their families' psychoeducation is still considered a key factor in the management of antidepressant discontinuation syndrome, and clinicians should educate patients about possibility and nature of discontinuation symptoms, the importance of taking medication consistenly.
Discontinuation Syndrome in Dysthymic Patients Treated with Selective Serotonin Reuptake Inhibitors
A discontinuation syndrome is common after treatment with SSRIs is stopped in patients with dysthymia, and it appears to be more common in patients receiving paroxetine than in those receiving fluoxettine.
Neonatal symptoms following maternal paroxetine treatment: Serotonin toxicity or paroxetine discontinuation syndrome?
It is recommended that all neonates exposed to antidepressants during the last trimester should be followed-up closely for adverse symptoms commencing in the first 10 days after birth, though an important differential diagnosis is a paroxetine discontinuation (withdrawal) syndrome.


Clinical management of antidepressant discontinuation.
To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life. Agents with
The SSRI discontinuation syndrome
  • P. Haddad
  • Medicine, Psychology
    Journal of psychopharmacology
  • 1998
A characteristic selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome appears to exist. It is usually mild, commences within 1 week of stopping treatment, resolves spontaneously
Antidepressant Withdrawal Syndrome
Antimuscarinic agents can be prescribed in order to alleviate the symptoms produced by the withdrawal of TCAs and MAOIs, but to date, no drugs have been shown to be useful in the treatment of SSRI-associated withdrawal symptoms.
Antidepressant Withdrawal Reactions
Three case reports of antidepressant withdrawal are presented, including one featuring akathisia (motor restlessness) related to withdrawal of venlafaxine, and treatment involves restarting the antidepressant and tapering it more slowly.
Serotonin reuptake inhibitor discontinuation syndrome: a hypothetical definition. Discontinuation Consensus panel.
A group of experts convened in Phoenix, Arizona, to develop a clear description or definition of the SRI discontinuation syndrome, which is distinctly different from the classic withdrawal syndrome associated with alcohol and barbiturates and may be minimized by slowly tapering antidepressant therapy.
Interruption of selective serotonin reuptake inhibitor treatment
Abrupt interruption of SSRI treatment can result in a syndrome characterised by specific physical and psychological symptoms, and placebo substitution for paroxetine was associated with increases in the number and severity of adverse events following the second missed dose, and increases in functional impairment at five days.
Serotonin reuptake inhibitor withdrawal.
Reports of withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective SSRIs, fluoxetine, fluvoxamine, paroxettine, or sertraline suggest a role has been suggested for serotonin in coordinating sensory and autonomic function with motor activity.
Possible biological mechanisms of the serotonin reuptake inhibitor discontinuation syndrome. Discontinuation Consensus Panel.
Experts have hypothesized that since some symptoms associated with paroxetine withdrawal are similar to those of tricyclic antidepressant discontinuation, they may be caused by cholinergic rebound, which is a factor in SRI discontinuation phenomena.
Adverse Events After the Abrupt Discontinuation of Paroxetine
All patients experienced rapid remission of symptoms after paroxetine was reintroduced and gradual tapering of the agent for patients receiving more than 20 mg/day is recommended.
Misdiagnosis of antidepressant discontinuation symptoms.
OBJECTIVE To demonstrate that when antidepressants are switched, discontinuation symptoms from the first antidepressant may be misdiagnosed as adverse effects of the second antidepressant. METHOD