Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine

  title={Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine},
  author={N. S. Donskaya and O. A. Antonkina and E. N. Glukhan and Sergey K. Smirnov},
  journal={Pharmaceutical Chemistry Journal},
4-Chloro-N-(3-morpholinopropyl)benzamide (befol, I) is an original domestic antidepressant belonging to the class of type A reversible MAO inhibitors [1]. The commercial production of befol includes the following stages: (i) synthesis of 4-chlorobenzoic acid chloroanhydride (II) [2]; (ii) syntesis of 3-morpholinopropionitrile (III) [3 – 6]; (iii) catalytic reduction of compound III to N-(3-aminopropyl)morpholine (IV) by hydrogen (30 – 40 bar) at 100 – 150°C in an excess of ammonia [3]; and (iv… 
1 Citations
Structure‐Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases
In this review, progress in the detecting and inhibiting of MAOs and their applications in mechanism exploration and treatment of neurotransmitter‐related disorders is summarized.


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