Antidepressant Activity of Aspartic Acid Derivatives

  title={Antidepressant Activity of Aspartic Acid Derivatives},
  author={V. I. Petrov and Vasiliy S. Sergeev and Natalia Onishchenko and Levon B. Piotrovskii},
  journal={Bulletin of Experimental Biology and Medicine},
Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant activity after single injection in the forced swimming and tail suspension tests. Antidepressant effect of 14-day administration of these compounds and reference drugs maprotiline (10 mg/kg) and citalopram (10 mg/kg) was confirmed on the model of learned helplessness. 
1 Citations
Catalytic enantioselective conjugate addition of aromatic amines to fumarate derivatives: asymmetric synthesis of aspartic acid derivatives
Abstract The catalytic enantioselective conjugate addition of aromatic amines to fumarate derivatives promoted by chiral palladium complexes is described. Treatment of aniline derivatives with


Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth
Results obtained with the technique demonstrate that selective serotonin reuptake inhibitors are not false negatives in the rat forced swimming test, as previously thought.
The tail suspension test: A new method for screening antidepressants in mice
A novel test procedure for antidepressants was designed in which a mouse is suspended by the tail from a lever, the movements of the animal being recorded, and the test can separate the locomotor stimulant doses from antidepressant doses.
Behavioural Effects in Mice of Subchronic Chlordiazepoxide, Maprotiline, and Fluvoxamine. I. Social Interactions
There were several differences in behavioral profile of the compounds tested, including maprotiline increased immobility, resembling the effects of fluvoxamine, while at 2 mg/kg, it reduced social investigation.
Prevention of learned helplessness: In vivo correlation with cortical serotonin
It is suggested that LH correlates with a significant decrease in intracellular releasable 5-HT in FC, and that three different techniques for LH prevention, acute BDZs, subchronic TCAs, and ES all similarly prevent this 5- HT depletion.
Grigor’ev, Psychopharmacology of the New Class of Nootropics, Neurotransmitter Amino Acid Derivatives Acting via EAA-ergic mechanisms
  • Abstract of Doct. Med. Sci. Dissertation,
  • 1998
Pharmacological study of the efficacy and action mechanisms of new neurotransmitter amino acid derivatives during experimental alcoholism, Abstract of Cand
  • Med. Sci. Dissertation,
  • 1996
Fundamental Studies as a Base for Creation of Pharmacological Drugs [in Russian
  • Volgograd
  • 1995