Antidepressant–placebo differences in 16 clinical trials over 10 years at a single site: role of baseline severity

@article{Khan2010AntidepressantplaceboDI,
  title={Antidepressant–placebo differences in 16 clinical trials over 10 years at a single site: role of baseline severity},
  author={Arif Khan and Amritha Bhat and James Faucett and Russell L Kolts and W. A. Brown},
  journal={Psychopharmacology},
  year={2010},
  volume={214},
  pages={961-965}
}
Antidepressant–placebo differences observed in randomized double-blind, placebo-controlled clinical trials have always been relatively small and have further declined during the past three decades. During this same time, a decrease in patient severity of symptoms at baseline has occurred. The current study was designed to examine antidepressant–placebo difference scores and baseline severity of depression over a 10-year period in a sample of depressed patients enrolled at a single clinical… CONTINUE READING

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