Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats.

@article{Rehg1993AnticryptosporidialAO,
  title={Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats.},
  author={Jerold E. Rehg},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={168 6},
  pages={1566-9}
}
The anticryptosporidial activities of three ionophorous antibiotics were assessed in dexamethasone-immunosuppressed rats infected with Cryptosporidium parvum. When administered prophylactically, lasalocid prevented infection in a dose-dependent manner, whereas monensin and salinomycin were ineffective. Therapeutically, lasalocid eliminated established overt infections of the intestine, although infection persisted in the common bile duct and intestinal infection recurred after lasalocid… CONTINUE READING