Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats

@article{GonzlezRamrez2010AnticonvulsiveEO,
  title={Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats},
  author={Misael Gonz{\'a}lez-Ram{\'i}rez and Le{\'o}n I. Razo-Ju{\'a}rez and Jos{\'e} L. Sauer-Ram{\'i}rez and Mar{\'i}a Eva Gonz{\'a}lez-Trujano and Hermelinda Salgado-Ceballos and Sandra Adela Orozco-Su{\'a}rez},
  journal={Pharmacology Biochemistry and Behavior},
  year={2010},
  volume={97},
  pages={267-272}
}
Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus
TLDR
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TLDR
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Investigation the protective effect of vitamin C on anxiety and oxidative stress modulation in male rats treated with progesterone
TLDR
Progesterone (5 mg/kg) has anxiogenic effect and at the high doses, progesterone has anxiolytic effect and as an antioxidant, vitamin C can improve the anxIOlytic effects of progester one.
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References

SHOWING 1-10 OF 62 REFERENCES
Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole‐induced seizures
TLDR
The results suggest that the anticonvulsant property of melatonin involves a modulation of both brain amino acids and NO production.
Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice
TLDR
These studies provide strong evidence that the PR is not required for the antiseizure effects of progesterone, which mainly occurs through its conversion to the neurosteroid allopregnanolone.
Modulation of Neurosteroid Synthesis/Accumulation by l‐Ascorbic Acid in Rat Brain Tissue: Inhibition by Selected Serotonin Antagonists
TLDR
The data suggest that l‐ascorbic acid plays a role in the modulation of neurosteroidogenesis, presumably by favoring the activation of the purported serotonin type 6 receptor by endogenous serotonin.
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