[Anticonvulsive combined therapy (author's transl)].


19 patients were treated with valproic acid (VPR) in combination with classical anticonvulsants (phenytoin, phenobarbitone, primidone, carbamazepine). Patients with a mean serum concentration of 340 micron moles/l showed a marked improvement as to the frequency of seizures or were even completely free from seizures, provided that the other anticonvulsants were also given in the therapeutic range. Cases showing only a slight reduction in seizure frequency or no improvement had a mean serum level of 229 micron moles/l. This investigation shows that in severe cases of epilepsy treated by combined therapy all given anticonvulsants must reach therapeutic levels to achieve effective control of seizures in most patients.

Cite this paper

@article{Deisenhammer1980AnticonvulsiveCT, title={[Anticonvulsive combined therapy (author's transl)].}, author={Eberhard A. Deisenhammer and Romana Sommer and Volker Nitsche}, journal={Wiener klinische Wochenschrift}, year={1980}, volume={92 1}, pages={23-4} }