Anticonvulsants during Pregnancy and Lactation Transplacental, Maternal and Neonatal Pharmacokinetics

  title={Anticonvulsants during Pregnancy and Lactation Transplacental, Maternal and Neonatal Pharmacokinetics},
  author={H. Nau and W. Kuhnz and H. Egger and D. Rating and H. Helge},
  journal={Clinical Pharmacokinetics},
  • H. Nau, W. Kuhnz, +2 authors H. Helge
  • Published 1982
  • Medicine
  • Clinical Pharmacokinetics
  • SummaryFew data are available on placental transfer of anticonvulsants during early pregnancy. Nevertheless, it has been demonstrated that at this early stage of gestation, considerable amounts of Phenytoin, primidone/phenobarbitone and carbamazepine as well as some of their metabolites are already present in fetal tissues. Potentially reactive metabolites of anticonvulsants can be formed by the fetal liver and accumulate in some organs. At term, most anticonvulsants are present in neonatal… CONTINUE READING
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