Anticonvulsants during Pregnancy and Lactation Transplacental, Maternal and Neonatal Pharmacokinetics

@article{Nau1982AnticonvulsantsDP,
  title={Anticonvulsants during Pregnancy and Lactation Transplacental, Maternal and Neonatal Pharmacokinetics},
  author={Heinz Nau and Wilhelm Kuhnz and H J Egger and Dietz Rating and Hans Helge},
  journal={Clinical Pharmacokinetics},
  year={1982},
  volume={7},
  pages={508-543}
}
SummaryFew data are available on placental transfer of anticonvulsants during early pregnancy. Nevertheless, it has been demonstrated that at this early stage of gestation, considerable amounts of Phenytoin, primidone/phenobarbitone and carbamazepine as well as some of their metabolites are already present in fetal tissues. Potentially reactive metabolites of anticonvulsants can be formed by the fetal liver and accumulate in some organs. At term, most anticonvulsants are present in neonatal… Expand
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TLDR
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