Anticonvulsants: aspects of their mechanisms of action.

@article{Sderpalm2002AnticonvulsantsAO,
  title={Anticonvulsants: aspects of their mechanisms of action.},
  author={Bo S{\"o}derpalm},
  journal={European journal of pain},
  year={2002},
  volume={6 Suppl A},
  pages={3-9}
}
An ideal anticonvulsant drug would prevent or inhibit excessive pathological neuronal discharge without interfering with physiological neuronal activity and without producing untoward effects. Such an ideal compound is not yet available. However, during the last few years several new anticonvulsants have appeared (e.g. vigabatrine, gabapentin, topiramate, lamotrigine, tiagabine, felbamate and oxcarbazepine) which may challenge the older, more established substances (i.e. phenytoin… CONTINUE READING

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However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
However , during the last few years several new anticonvulsants have appeared ( e.g. vigabatrine , gabapentin , topiramate , lamotrigine , tiagabine , felbamate and oxcarbazepine ) which may challenge the older , more established substances ( i.e. phenytoin , benzodiazepines , phenobarbital , valproate , carbamazepine and ethosuximide ) .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
Interestingly , several of the old and new anticonvulsants are beneficial in the treatment of various psychiatric conditions ( most notably mood disorders ) as well as neuropathic pain .
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