Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).

@article{Bum2001AnticonvulsantPO,
  title={Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).},
  author={Elisabeth Ngo Bum and Markus Schmutz and Christian Meyer and Alice Rakotonirina and M. Bopelet and Ch. Portet and A Jeker and Silvere V Rakotonirina and H R Olpe and Paul Herrling},
  journal={Journal of ethnopharmacology},
  year={2001},
  volume={76 2},
  pages={145-50}
}
The methanolic extract of rhizomes of Cyperus articulatus, a plant used in traditional medicine in Africa and Latin America for many diseases, possesses anticonvulsant activity in mice. This extract protected mice against maximal electroshock (MES)- and pentylenetetrazol (PTZ)-induced seizures. It also delayed the onset of seizures induced by isonicotinic acid hydrazide and strongly antagonized N-methyl-D-aspartate-induced turning behavior. The ED(50) for protection against seizures was 306… CONTINUE READING
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