Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet

@article{Likhodii2003AnticonvulsantPO,
  title={Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet},
  author={Sergei S. Likhodii and Irina Serbanescu and Miguel A. Cortez and Patricia Murphy and O Carter Snead and W. McIntyre Burnham},
  journal={Annals of Neurology},
  year={2003},
  volume={54}
}
The ketogenic diet (KD), a treatment for drug‐resistant epilepsy, elevates brain acetone. Acetone has been shown to suppress experimental seizures. Whether elevation of acetone is the basis of the anticonvulsant effects of the KD and whether acetone, like the KD, antagonizes many different types of seizures, however, is unknown. This study investigated the spectrum of the anticonvulsant effects of acetone in animal seizure models. Rats were injected with acetone intraperitoneally. Dose–response… Expand
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