Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae–Papilionaceae)

@article{Faggion2011AnticonvulsantPO,
  title={Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae–Papilionaceae)},
  author={Silmara Aparecida Faggion and Alexandra Olimpio Siqueira Cunha and Helene Aparecida Fachim and Amanda Salom{\~a}o Gavin and Wagner Ferreira dos Santos and Ana Maria Soares Pereira and Ren{\^e} de Oliveira Beleboni},
  journal={Epilepsy & Behavior},
  year={2011},
  volume={20},
  pages={441-446}
}
Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the… CONTINUE READING