Anticonvulsant impact of lesions in the ventrolateral forebrain of rats challenged with soman.

@article{Myhrer2008AnticonvulsantIO,
  title={Anticonvulsant impact of lesions in the ventrolateral forebrain of rats challenged with soman.},
  author={Trond Myhrer and Siri Enger and P{\aa}l \Oyvind Aas},
  journal={Brain research},
  year={2008},
  volume={1226},
  pages={241-7}
}
Mapping of trigger sites and/or propagation pathways for soman-induced seizures may provide clues for the designing of anticonvulsant drugs. In the present study, anticonvulsant efficacy against soman intoxication (1.3 x LD50) was examined in rats with either lesion of the perirhinal cortex, posterior piriform cortex, entorhinal cortex, hippocampal region, or amygdala. The results showed that prevention of convulsions or increased latency to onset of convulsions was ensured in rats with… CONTINUE READING