Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.

@article{Reissmueller2000AnticonvulsantEO,
  title={Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.},
  author={Elke Reissmueller and Ulrich Ebert and Wolfgang L{\"o}scher},
  journal={Epilepsia},
  year={2000},
  volume={41 4},
  pages={372-9}
}
PURPOSE We evaluated the anticonvulsant efficacy of topiramate (TPM), a structurally novel antiepileptic drug (AED), in amygdala kindled rats that had been preselected with respect to their response to phenytoin (PHT). METHODS Anticonvulsant response was tested by determining the afterdischarge threshold (ADT; i.e., a sensitive measure for drug effects on focal seizure activity). By repeated testing with the PHT prodrug fosphenytoin (FOS) three groups of kindled rats were separated: rats in… CONTINUE READING