Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model.

@article{Voskuyl1998AnticonvulsantEO,
  title={Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model.},
  author={Rob A. Voskuyl and Martin Vreugdenhil and Jing Xuan Kang and Alexander Leaf},
  journal={European journal of pharmacology},
  year={1998},
  volume={341 2-3},
  pages={
          145-52
        }
}
Recent studies have shown that long-chain polyunsaturated fatty acids can prevent cardiac arrhythmias, attributed to the reduction in excitability of cardiomyocytes, owing mainly to a shift in hyperpolarizing direction of the inactivation curves of both Na+ and Ca2+ currents and to a slowed recovery from inactivation. Qualitatively similar effects of polyunsaturated fatty acids on inactivation parameters have been observed in freshly isolated hippocampal neurons. Since the same effects are… CONTINUE READING

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