Anticonvulsant effect of dexmedetomidine in a rat model of self-sustaining status epilepticus with prolonged amygdala stimulation.

@article{Kan2013AnticonvulsantEO,
  title={Anticonvulsant effect of dexmedetomidine in a rat model of self-sustaining status epilepticus with prolonged amygdala stimulation.},
  author={Min-chen Kan and Weiping Wang and Gen-dong Yao and Jun-tao Li and Tao Xie and Wei Wang and Wen-Qun Ma},
  journal={Neuroscience letters},
  year={2013},
  volume={543},
  pages={17-21}
}
Status epilepticus (SE), leading to 27 percent mortality in adult patients, becomes refractory to firstline intravenous diazepam, with prolonged seizure duration. The mechanism could be attributed to the declined inhibitory action of GABA; therefore, alternative medications acting on other targets are necessary. The aim of the present study was to examine… CONTINUE READING