Anticonvulsant effect of GMP depends on its conversion to guanosine.

  title={Anticonvulsant effect of GMP depends on its conversion to guanosine.},
  author={F{\'e}lix Alexandre Antunes Soares and Andr{\'e} Schmidt and Marcelo Farina and Marcos Em{\'i}lio Frizzo and Rejane Giacomelli Tavares and Lu{\'i}s Valmor Cruz Portela and Diogo Rizzato Lara and Diogo Onofre Souza},
  journal={Brain research},
  volume={1005 1-2},
Studies on the purinergic system normally deal with adenine-based purines, namely, adenine nucleotides and adenosine. However, a guanine-based purinergic system may also have important neuromodulatory roles. Guanine-based purines exert trophic effects on neural cells, protect brain slices in a model of hypoxia and stimulate glutamate uptake. In vivo, both guanosine 5'-monophosphate (GMP) and guanosine (GUO) protected against seizures. In this study, we investigated if the anticonvulsant effect… CONTINUE READING


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