Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat.

@article{Jonker2003AnticonvulsantDD,
  title={Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat.},
  author={Dani{\"e}l Martijn Jonker and C van de Mheen and Paul H. C. Eilers and Menno R. Kruk and Rob A. Voskuyl and Meindert Danhof},
  journal={Behavioral neuroscience},
  year={2003},
  volume={117 5},
  pages={
          1076-85
        }
}
Antiepileptic drugs can suppress seizures completely, but they may also modify the appearance of drug-resistant seizures. In this study, the effects of three antiepileptic drugs on a seizure pattern were assessed by means of population pharmacokinetic/pharmacodynamic (PK/PD) modeling, yielding estimates of baseline response, EC50, and Hill slope. Lamotrigine did not affect eye closure, although it did suppress the other ictal signs in a concentration-dependent fashion. Midazolam suppressed… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…