Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates.

Abstract

We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same… (More)

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