Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones.

@article{Yogeeswari2005AnticonvulsantAN,
  title={Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones.},
  author={Perumal Yogeeswari and Dharmarajan Sriram and Siddhi Mehta and D K Nigam and Man Mohan Kumar and Sankaranarayanan Murugesan and James P. Stables},
  journal={Farmaco},
  year={2005},
  volume={60 1},
  pages={
          1-5
        }
}
Various 6-substituted benzothiazolyl-2-thiosemicarbazones were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. The 6-methyl benzothiazolyl-2-thiosemicarbazones showed anticonvulsant activity in both mice i.p. and rat oral MES screen. The 6-nitro benzothiazolyl thiosemicarbazone derivative 1a emerged as the most… Expand
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