Anticonvulsant and Sedative-Hypnotic Activities of N-Acetyl / Methyl Isatin Derivatives

Abstract

A series of N-methyl/acetyl 5-(un)-substituted isatin-3-semicarbazones were screened for anticonvulsant and sedative-hypnotic activities. The results revealed that protection was obtained in all the screens i.e., Maximal electroshock, (MES) subcutaneous pentylene tetrazole (scPTZ) and subcutaneous strychnine (scSTY) screens. Three compounds (5a, 5e and 5i… (More)

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@inproceedings{Smitha2008AnticonvulsantAS, title={Anticonvulsant and Sedative-Hypnotic Activities of N-Acetyl / Methyl Isatin Derivatives}, author={Sivakumar Smitha and Surendra Nath Pandeya and James P. Stables and Suthakar Ganapathy}, year={2008} }