Anticonvulsant and Neurotoxicity Evaluation of Some Novel Kojic Acids and Allomaltol Derivatives

@article{Aytemir2010AnticonvulsantAN,
  title={Anticonvulsant and Neurotoxicity Evaluation of Some Novel Kojic Acids and Allomaltol Derivatives},
  author={Mutlu Dilsiz Aytemir and {\"U}. Çalış},
  journal={Archiv der Pharmazie},
  year={2010},
  volume={343}
}
  • Mutlu Dilsiz Aytemir, Ü. Çalış
  • Published 2010
  • Chemistry, Medicine
  • Archiv der Pharmazie
    • A series of new 3‐hydroxy‐6‐hydroxymethyl/methyl‐2‐substituted 4H‐pyran‐4‐ones were synthesized and prepared by the reaction of kojic acid or allomaltol with piperidine derivatives and formaline as potential anticonvulsant compounds. The structure of the synthesized compounds was confirmed using the elemental analysis results and the spectroscopic techniques such as IR, 1H‐NMR, and ESI‐MS. Anticonvulsant activities were examined by maximal electroshock (MES) and subcutaneous Metrazol (scMet… CONTINUE READING
    View on Wiley
    yunus.hacettepe.edu.tr
    21 Citations
    Background Citations
    2
    21 Citations
    Citation Type

    Citation Type

    Design, synthesis and in vivo/in vitro screening of novel chlorokojic acid derivatives
    • 16
    Mannich bases in medicinal chemistry and drug design
    • G. Roman
    • Chemistry, Medicine
    • European Journal of Medicinal Chemistry
    • 2015
    • 159
    A kojic acid derivative promotes intrinsic apoptotic pathway of hepatocellular carcinoma cells without incurring drug resistance
    • 1
    5-Hydroxypyran-4-one derivatives as potential therapeutic iron–chelating agents
    • 2
    Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid
    • 2
    Pyrone derivatives and metals: From natural products to metal-based drugs
    • 61
    Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity.
    • 17
    Chiral Bifunctional Squaramide‐Catalyzed Highly Enantioselective Michael Addition of Allomaltol to β,γ‐Unsaturated α‐Ketoesters
    • 14
    Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity
    • 9
    • PDF
    One-pot, three-component, green procedure for efficient synthesis of allomaltol derivatives
    • 3

    References

    SHOWING 1-10 OF 18 REFERENCES
    Synthesis and Evaluation of Anticonvulsant and Antimicrobial Activities of 3‐Hydroxy‐6‐methyl‐2‐substituted 4H‐Pyran‐4‐one Derivatives
    • 73
    New analgesic and antiinflammatory agents 4(1H)-pyridinone derivatives.
    • 23
    Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety
    • 51
    Basic 3-hydroxypyridin-4-ones: potential antimalarial agents.
    • 34
    New anticonvulsant agents.
    • B. Malawska
    • Medicine
    • Current topics in medicinal chemistry
    • 2005
    • 118
    Synthesis, physicochemical properties, and biological evaluation of hydroxypyranones and hydroxypyridinones: novel bidentate ligands for cell-labeling.
    • 69
    Synthesis of 2-amido-3-hydroxypyridin-4(1H)-ones: novel iron chelators with enhanced pFe3+ values.
    • 47
    Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H -pyran-2- carboxamide Derivatives
    • 44
    • PDF
    Antiepileptic Drug Development: II. Anticonvulsant Drug Screening
    • 768
    SOME NEW REACTIONS AND DERIVATIVES OF KOJIC ACID
    • 16