Anticonvulsant activity of the testosterone-derived neurosteroid 3&agr;-androstanediol

@article{Reddy2004AnticonvulsantAO,
  title={Anticonvulsant activity of the testosterone-derived neurosteroid 3\&agr;-androstanediol},
  author={Doodipala Samba Reddy},
  journal={NeuroReport},
  year={2004},
  volume={15},
  pages={515-518}
}
  • D. Reddy
  • Published 1 March 2004
  • Biology, Medicine
  • NeuroReport
3&agr;-Androstanediol is synthesized from testosterone in peripheral tissues and in the brain, but the clinical importance of this neurosteroid remains unclear. This study evaluated the effects of 3&agr;-androstanediol on seizure susceptibility in mouse models of epilepsy. 3&agr;-Androstanediol protected mice against seizures induced by GABAA receptor antagonists pentylenetetrazol, picrotoxin, and ß-carboline ester in a dose-dependent fashion. However, 3&agr;-androstanediol was inactive against… 
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