Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.

@article{Jahromi2002AnticonvulsantAO,
  title={Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.},
  author={Shokrollah S. Jahromi and Kirsten Wentlandt and Sanaz Piran and Peter L. Carlen},
  journal={Journal of neurophysiology},
  year={2002},
  volume={88 4},
  pages={1893-902}
}
Gap junctions (gjs) are increasingly recognized as playing a significant role in seizures. We demonstrate that different types of gap junctional blocking agents reduce the duration of evoked seizure-like primary afterdischarges (PADs) in the rat in vitro CA1 hippocampal pyramidal region, following repetitive tetanization of the Schaffer collaterals… CONTINUE READING