Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

@article{Chapman1999AnticonvulsantAO,
  title={Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).},
  author={Astrid G. Chapman and Ping K Yip and Jeanette See Leng Yap and L P Quinn and E Tang and J. Robin Harris and Brian S. Meldrum},
  journal={European journal of pharmacology},
  year={1999},
  volume={368 1},
  pages={
          17-24
        }
}
We have studied the effects in three rodent models of generalised convulsive or absence epilepsy of two antagonists of group I metabotropic glutamate receptors that are selective for the mGlu1 receptor. LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid) have been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice… Expand
Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)
TLDR
In lethargic mice (lh/lh), a genetic absence model, MPEP, 50 mg/kg i.p., caused a marked reduction in the incidence of spontaneous spike-and-wave discharges and the ED(50) for MPEP for impaired rotarod performance is 128 [83-193] mg/ kg i.c.v. Expand
Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice.
TLDR
It can be concluded that AIDA had an anticonvulsant effect on pentetrazol-induced kindled seizures, which was partially mediated by the GABAergic mechanism through GABA(A) and GABA(C) receptors. Expand
Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine.
TLDR
The data suggest that the mglu(8) receptor is a potential target for novel antiepileptic drugs, as well as suggesting that L-Serine-O-phosphate gives only partial protection against sound-induced clonic seizures in DBA/2 mice. Expand
The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice
The anticonvulsant activity of the selective group II metabotropic glutamate receptor (mGlu) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) has been evaluated in chemoconvulsant andExpand
Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)
TLDR
A potential role for mGlu(2/3) agonists in the amelioration of generalised and partial epileptic seizures is identified. Expand
Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice
TLDR
The present findings suggest that (S)-3,5-DHPG produces an increase in excitation that is mediated by mGlu1 and non-NMDA receptors. Expand
The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist.
TLDR
It is indicated that selective mGluR1 antagonist AIDA induces antianxiety-like effects at a low risk of acute side effects characteristic of benzodiazepines. Expand
Roles of group II metabotropic glutamate receptors in modulation of seizure activity
TLDR
The data suggest that the group II mGluR agonist LY354740 possesses anti-seizure activity and may modify the effects of some conventional antiepileptic drugs. Expand
Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats
TLDR
Both mGluR antagonists exhibit specific anticonvulsant action in rat pups during the first 3 postnatal weeks when the incidence of the tonic phase of GTCS was decreased. Expand
The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson′s disease
TLDR
The present study indicates that the blockade of striatal glutamate receptors belonging to the group I but not stimulation of the group II mGluRs may normalize the function of the striatopallidal pathway in an animal model of parkinsonism, which may be important for future antiparkinsonian therapy in humans. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats.
TLDR
It is concluded that mGlu receptor activation potently modifies seizure threshold. Expand
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists
The functional role of metabotropic glutamate receptor (mGluR) activation was investigated following intracerebral administration of 1S,3R-ACPD in mice. Injections of 1S,3R-ACPD (50-800 nmol in 5Expand
Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs.
TLDR
Intracrebroventricular injections of agonists and antagonists believed to act selectively on metabotropic glutamate receptors are used to study the pro- or anti-convulsant effects of mGluR III activation in nonepileptic and epileptic mice, suggesting that reduced inhibitory transmission may be more significant than reduced synaptic release of glutamate following group III mGLUR activation. Expand
Induction or protection of limbic seizures in mice by mGluR subtype selective agonists
TLDR
The data indicate that mGluR agonist-induced limbic seizures in mice are mediated by activation of phosphoinositide-coupled m GluRs, and these seizures can be protected against byactivation of mGLURs that are negatively-linked to cAMP formation. Expand
Modulation of seizure activity in mice by metabotropic glutamate receptor ligands.
TLDR
The data suggest that mGluR ligands modulate seizure activity in mice and this effect may be mediated via antagonism of m gluR1a-type as well as via activation of m GluR2-type mGLURs. Expand
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist
TLDR
The studies indicate that seizures and neuronal injury can be elicited by the selective activation of metabotropic glutamate receptors in perinatal rats, and these effects of 1S,3R-ACPD involve the mobilization of intracellular calcium stores. Expand
(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice
TLDR
The in vivo anticonvulsant effects and in vitro metabo‐tropic glutamate receptor selectivity of (S)‐4‐carboxy‐3‐hydroxy‐phenylglycine [S]‐4C3HPG suggest the importance of mGLUR1a and/or mGluR2 in the control of epileptic activity. Expand
3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus
TLDR
In the rat hippocampus, 3,5‐dihydroxyphenylglycine can be used to activate subpopulations of mGluRs coupled to phosphoinositide hydrolysis with minimal effects on cAMP‐mGluR second messenger systems. Expand
(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors
Abstract The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution ofExpand
Utility of the Lethargic (lh/lh) Mouse Model of Absence Seizures in Predicting the Effects of Lamotrigine, Vigabatrin, Tiagabine, Gabapentin, and Topiramate Against Human Absence Seizures
TLDR
The high‐dose pen‐tylenetetrazole (PTZ) model correctly predicted the efficacy of ethosuximide (ESM), benzodiazepines, and valproate (VPA) and the lack of efficacy of phenytoin (PHT) and carbamazepine (CBZ), but appears to have erred in predictions for gabapentin (GBP) and topiramate (TPM). Expand
...
1
2
3
...