Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors.

@article{Clinckers2004AnticonvulsantAO,
  title={Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D and 5-HT receptors.},
  author={Ralph Clinckers and Ilse J. Smolders and Alfred Meurs and Guy Ebinger and Yvette Michotte},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 4},
  pages={834-43}
}
The present microdialysis study evaluated the anticonvulsant activity of extracellular hippocampal dopamine (DA) and serotonin (5-HT) with concomitant assessment of the possible mutual interactions between these monoamines. The anticonvulsant effects of intrahippocampally applied DA and 5-HT concentrations were evaluated against pilocarpine-induced seizures in conscious rats. DA or 5-HT perfusions protected the rats from limbic seizures as long as extracellular DA or 5-HT concentrations ranged… CONTINUE READING
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