Anticonvulsant action of excitatory amino acid antagonists.


Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D… (More)


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@article{Croucher1982AnticonvulsantAO, title={Anticonvulsant action of excitatory amino acid antagonists.}, author={Martin J. Croucher and J. F. Collins and Brian S. Meldrum}, journal={Science}, year={1982}, volume={216 4548}, pages={899-901} }