Anticonvulsant action of excitatory amino acid antagonists.

  title={Anticonvulsant action of excitatory amino acid antagonists.},
  author={Martin J. Croucher and Joseph F. Collins and Brian S. Meldrum},
  volume={216 4548},
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D-aspartic acid. The most potent such compound, 2-amino-7-phosphonoheptanoic acid, was anticonvulsant in both test systems when given either… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 79 extracted citations

Sedative and Anticonvulsant Properties of Passiflora Edulis Dried Leaves Decoction in Mice

Elisabeth Ngo Buma, Christian Dongc, SilvereVincent Rakotonirinac, Alice Rakotonirinac
View 2 Excerpts
Highly Influenced

Effects of homeopathic Anax imperator on behavioural and pain models in mice.

Homeopathy : the journal of the Faculty of Homeopathy • 2015

Similar Papers

Loading similar papers…