Anticonvulsant action of excitatory amino acid antagonists.

@article{Croucher1982AnticonvulsantAO,
  title={Anticonvulsant action of excitatory amino acid antagonists.},
  author={Martin J. Croucher and Joseph F. Collins and Brian S. Meldrum},
  journal={Science},
  year={1982},
  volume={216 4548},
  pages={899-901}
}
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D-aspartic acid. The most potent such compound, 2-amino-7-phosphonoheptanoic acid, was anticonvulsant in both test systems when given either… CONTINUE READING

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