Anticonvulsant action of anandamide in an in vitro model of epilepsy.

  title={Anticonvulsant action of anandamide in an in vitro model of epilepsy.},
  author={Abdulmonem A. Al-Hayani},
  volume={10 3},
OBJECTIVE In both in vitro and in vivo models of epilepsy, cannabinoids had anti-convulsant properties, which have been shown to be mediated through activation of central cannabinoid type 1 receptors (CB1). The current study used 24 adult Sprague Dawley rats to investigate the effects of endogenously occurring cannabinoids (endocannabinoids) on epileptiform activity induced by picrotoxin. METHODS We carried out the study at King Fahad Medical Research Center, Jeddah, Kingdom of Saudi Arabia… CONTINUE READING

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